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Persistent unexplained elevation alongside an abnormal CBC or differential, constitutional symptoms such as unexplained weight loss, night sweats, or persistent fever, or organ-specific findings all raise the need for referral

Similarly, adipose-derived hormones like adiponectin, which typically exerts anti-inflammatory and insulin-sensitizing effects, decline with age and visceral obesity

Understanding how these molecular states intersect with stochastic behavior will be key to resolving how MuSC heterogeneity is maintained and altered during aging

A phase II randomized trial of megestrol acetate or dexamethasone in the treatment of hormonally refractory advanced carcinoma of the prostate